Optofluidic Raman spectroscopy for chemical analysis and Raman spectroscopy bio-sensor for tissue analysis

November 2013

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A facile and real-time spectroscopic method for biofluid analysis in point-of-care diagnostics
Spectroscopic Raman study of sulphate precipitation sequence in Rio Tinto mining district (SW Spain)
Crystallinity and compositional changes in carbonated apatites: Evidence from< sup> 31</sup> P solid-state NMR, Raman, and AFM analysis
Raman spectroscopy demonstrates prolonged alteration of bone chemical composition following extremity localized irradiation
A combined dielectrophoresis-Raman setup for the classification of pathogens recovered from the urinary tract
Synthesis, Characterization, and Atomistic Modeling of Stabilized Highly Pyrophoric Al (BH4) 3 Via the Formation of the Hypersalt K [Al (BH4) 4]
Environmental effects on the Raman spectra of single walled carbon nanotubes
Integrated system for combined Raman spectroscopy–spectral domain optical coherence tomography
Raman spectroscopy study of molecular hydrogen solubility in water at high pressure
Raman Microspectroscopy – A Non-Invasive Analysis Tool For Monitoring Of Collagen-Containing Extracellular Matrix Formation in a Medium-Throughput Culture System
Raman microspectroscopic and dynamic vapor sorption characterization of hydration in collagen and dermal tissue
Probing speciation inside a conducting polymer matrix by in situ spectroelectrochemistry
Picosecond spectral coherent anti-Stokes Raman scattering imaging with principal component analysis of meibomian glands
pH-induced metal-ligand cross-links inspired by mussel yield self-healing polymer networks with near-covalent elastic moduli
Optimizing Gold Nanoparticle Cluster Configurations (n 7) for Array Applications
Optimising reproducibility in low quality signals without smoothing; an alternative paradigm for signal processing
Optimal Size of Silver Nanoparticles for Surface-Enhanced Raman Spectroscopy
High Pressure Vibrational Spectroscopy of Hexahydro 1, 3, 5 Trinitro 1, 3, 5 Triazine (RDX)
Gas-phase thermometry using delayed-probe-pulse picosecond coherent anti-Stokes Raman scattering spectra of H2
Functional plant cell wall design revealed by the Raman imaging approach

Raman spectroscopy is a powerful spectroscopic tool in the field of bio-chemical analytics for chemical fingerprinting. The ability of this technique to achieve multi-component detection makes this a technique with high chemical specificity. However the weak cross-section of Raman scattering makes it extremely important to have sensitive detectors and efficient optical systems that ensures highest optical throughput for Raman photons while rejecting as much background luminescence as possible. Recent technological advances in sources, detectors and probes make it possible to reduce the form factor of Raman instruments which allows field portability for chemical analysis and clinical diagnosis. This talk addresses two aspects of Raman spectroscopy in chemical analysis and clinical diagnosis.

The first part of this talk details the realisation of a completely optical alignment-free, compact optofluidic device to perform Raman spectroscopy from small volume (~10 microliters) of fluids. The use of this device for various analyte detection and reaction monitoring would be detailed. Further, the use of this device in food and drinks industry would be detailed with examples of using this device for Scotch whisky analysis and detecting toxicity in alcoholic beverages.

The second part of this talk details a Raman spectroscopy bio-sensor which was designed to be integrated with a surgical robot for tissue analysis. The design constraints to achieve such a system would be detailed and would discuss the issue of data representation when using Raman spectroscopy for clinical diagnostics.

Key Learning Objectives:

  • Microfluidic Raman spectroscopy
    • Analytical chemistry
    • Food and drinks
  • Fibre Raman probe
    • Clinical diagnostics
    • Optical biopsy

Dr. Praveen Cheriyan Ashok
Post-doctoral Fellow
Optical Manipulation Group
School of Physics & Astronomy, University of St. Andrews

Dr. Praveen Cheriyan Ashok is a post-doctoral fellow in the optical manipulation group of University of St Andrews. He obtained his masters in Photonics from Cochin University of Science and Technology (India) in 2008 and PhD from University of St Andrews (Scotland) in 2011. His research focuses on developing spectroscopic and imaging techniques for bio-medical diagnostics and chemical sensing. He is mainly interested in techniques such as Raman spectroscopy, Optical Coherence Tomography and microfluidics.

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