The Science Behind Future Anti-Cancer Vaccines
Bruno De Geest is a Professor of Biopharmaceutical Technology at Ghent University, Belgium, and the leader of his own research group at the Department of Pharmaceutics.
His interdisciplinary lab works on the interface between materials chemistry and life science to design novel drug delivery systems and to investigate how these interact with living cells and tissues in vitro and in vivo. Bruno’s work follows three main themes: a) Self-assembled polymeric multilayer thin films, b) Particulate vaccine delivery and c) Anti-cancer therapy.
Some of Bruno’s latest work has been published in “Advanced Functional Materials”, “Angewandte Chemie International Edition” and “ACS Nano”. In these papers Bruno et al described different approaches to efficiently incorporate vaccine antigens into polymeric capsules and deliver these to dendritic cells. The goal of this research is to promote the induction of cytotoxic T cells, which can kill malignant cancer cells. These new methods can help develop future anti-cancer vaccines.
Bruno’s group uses a wide range of molecular and cellular techniques as well as cutting edge imaging to gain insight into natural biological processes as well as to assess the success of novel vaccines and anti-cancer therapies. One of the key tools used in his lab is the Andor Revolution DSD2 a laser free confocal image system. The Andor Revolution DSD2 allows a fast multi-color image acquisition at high speed and in multiple dimensions. Therefore it is particularly well suited for us to investigate the interaction between nanoparticles and living cells, including dendritic cells and cancer cells.
Bruno graduated as Chemical Engineer in 2003 from Ghent University where he obtained his PhD in pharmaceutical sciences in 2006 on 'Polyelectrolyte Multilayer Capsules for Pharmaceutical Applications'. For his Phd work he was awarded the graduate student award for pharmaceutical technology from the AAPS and the Andreas Deleenheer award from Ghent University. After 2 years of postdoctoral research at Utrecht University (The Netherlands) he returned to Ghent University at the Department of Pharmaceutics. He moved to his current position at Ghent University in October 2012.
- Bio-Hybrid Tumor Cell-Templated Capsules: A Generic Formulation Strategy for Tumor Associated Antigens in View of Anti-Cancer Immune-TherapyLybaert, L.; De Vlieghere, E.; De rycke, R.; Vanparijs, N.; De Wever, O.; De Koker, S.; De Geest, B.G.
Advanced Functional Materials, in press
- Nanoporous hydrogen bonded polymeric microparticles: facile and economic production of cross presentation promoting vaccine carriers
Dierendonck, M.; Fierens, K.; De Rycke, R.; Lybaert, L.; Maji, S.; Zhang, Z.; Zhang, Q.; Hoogenboom, R.; Lambrecht, B.N.; Grooten, J.; Remon, J.P.; De Koker, S.; De Geest, B.G. Advanced Functional Materials, in press
- Nanoporous polyelectrolyte vaccine microcarriers - in vitro and in vivo evaluation
De Koker, S.; Fierens, K.; Dierendonck, M.; De Rijcke, R. Lambrecht, B.N.; Grooten, J.; De Geest, B.G.
Journal of Controlled Release, in press
- Thermoresponsive hyaluronic acid nanogels as hydrophobic drug nanocarrier to macrophages
Fernandes Stefanello, T.; Szarpak-Jankowska, A.; Appaix, F.; Louage, B.; Hamard, L.; De Geest, B.G.; van der Sanden, B.; Vataru Nakamura, C.; Auzély-Veltya, R.
Acta Biomateriala, in press
- Hydrogen bonded Multilayer Films based on poly(2-oxazoline)s and tannic acid
Sundaramurthy, A.; Vergaelen, M.; Maji, S.; Auzely-Velthy, R.; Zhang, Z.; De Geest, B.G.; Hoogenboom, R.
Advanced Healthcare Materials, in press
- Spray-Dried Polyelectrolyte Microparticles in Oral Antigen Delivery: Stability, Biocompatibility and Cellular Uptake
De Smet, R.; Verschuere, S.; Allais, L.; Leclercq, G.; Dierendonck, M ; De Geest, B.G. ; Van Driessche, I. ; Demoor, T.; Cuvelier, C.A.
Biomacromolecules, in press
- Fast and accurate partial hydrolysis of poly(2-ethyl-2-oxazoline) into tailored linear polyethyleneimine copolymers
De la Rosa, V.R.; Bauwens, E.; Monney, B.D.; De Geest, B.G.; Hoogenboom, R.
Polymer Chemistry, in press
- Just spray it - next generation of electrostatic assembly
Dierendonck, M.; De Koker, S.; De Rijcke, R.; De Geest, B.G.
Soft Matter, 2014, 10, 804-807.
- Straightforward RAFT-procedure for the synthesis of heterotelechelic poly(acrylamides)
Wallyn, S.; Zhang, Z.; Driessen, F.; Pietrasik, J.; De Geest, B.G.; Hoogenboom, R.; Du Prez, F.E.
Macromolecular Rapid Communications, 2014, 35, 405-411.
- Dual pH- and temperature-responsive RAFT-based block co-polymer micells and polymer-protein conjugates with transient solubility
Zhang, Q.; Vanparijs, N.; Louage, B.; De Geest, B.G.; Hoogenboom, R.
Polymer Chemistry, 2014, 5, 1140-1144.