Fluorescence spectroscopy is a widespread and powerful technique that can be applied to studies on large biomolecules and their interactions. In particular techniques using the modality of fluorescence resonance energy transfer (FRET) combined with encoded nanocrystal fluorescent microbeads are now being explored as a potential means of developing early diagnostic devices/systems formedical applications.
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Ultra-sensitive detection/screening of antibodies has been recently demonstrated using an immunodiagnostic technique applied to nanocrystal encoded microbeads. Work reported by Alyona Sukhanova et.al.[1] in Nano Letters, shows the application of nanocrystal encoded microbeads in flow cytometry assays for investigation of multiplexed antibody profiling. They demonstrate how their design of their assay can distinguish between different antibody-antigen configurations. Their results are particularly relevant to the development of clinical diagnostics for the early detection of autoimmune diseases.
Complete Andor solutions offer the ultra-high sensitivity of an EMCCD, high speed acquisition of spectra, high speed scanning/mapping and a fully integrated detection system including software. The full benefit of EM technology is realized when sample lifetime or changeability is critical. It is possible to use lower excitation energies to prolong sample lifetime and/or reduce photobleaching.
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