Laser Beam Combiner for Microscopy | Andor
Andor

Integrated Laser Engine

The Andor Integrated Laser Engine (ILE) is a third generation multi-line laser source delivering between two and eight laser lines via one, two or three optical fibre outputs for millisecond switching between imaging modes and tools like Confocal, TIRF and FRAPPA. The ILE benefits from more than 10 years global field experience in the design and manufacture of laser engines, an installed base approaching six hundred users and exploits the best technologies from Andor and Spectral Applied Research.

  • Multi-line laser source - up to 8 lines
  • Wide VIS-NIR range
  • Up to 3 port output
  • Unique Active blanking
  • Low power consumption
  • Long life solid state lasers

Overview

Andor Laser Combiner and (optional) Multi-Port Switch

Key features of the ultra-stable platform include active thermal control, vibration isolation and optimal laser beam management to deliver robust long-lived performance. Utilizing primarily direct modulation (DM) lasers, the ILE achieves unrivalled spectral range, efficiency and stability. Fifty to more than one hundred milliwatts is available on most DM laser lines, providing plenty of power for your bio-imaging and spectroscopy needs. ILE is available in Class 3B and Class 4 models.

Control of the unit is via either RS-232, USB2 or direct analog/TTL control of individual lasers via rear panel connections. The unit provides fast laser blanking via 4 inputs to allow multi-camera, FRAP and user-specified control for flexibility.

Features and Benefits

Feature & Benefits
Wide VIS-NIR spectral range The ILE is compatible with a wide range of laser sources and wavelengths, the current selection covers from 405 up to 785 nm
Direct modulation Lasers Obtain exceptional spectral range, high efficiency and stability
Three-port switch: multi-function flexibility Switch effortlessly between Confocal, TIRF, widefield and/or FRAP modes
Multi-line laser source Flexible configuration allows up to 4 lines in the ILE-400 and up to 8 lines in the ILE-800
Thermally managed Effective thermal regulation helps to provide long-term, ultra-stable performance
Borealis-compatible Benefit from enhanced throughput and uniformity in widefield and spinning disk confocal systems

Specifications

Model ILE-400 ILE-700 ILE-800
Max number of lasers 4 7 8
Output Mode Single and/or multi Minimum 1 port multi (8 lines)
Wavelength range (nm) 405-785
Multiports switch outputs 2, 3 +1 or +2
Multiport switch time (ms) 3
Blank/TTL Modulation (diode) MHz 4
Blank/TTL Modulation (OPSL) MHz 0.05
Computer control interface RS-232, USB2
TTL/Analog control interface HD15 D-sub HD15 D-sub x2

Learning

The Andor Learning Center hosts a wide range of case studies, technical articles and webinars to guide you through the many features of our portfolio.

Papers

AuthorTitle
Gap geometry dictates epithelial closure efficiency
The EHD protein Past1 controls postsynaptic membrane elaboration and synaptic function
The role of Ca2+ influx in spontaneous Ca2+ wave propagation in interstitial cells of Cajal from the rabbit urethra
Regulation of Patterned Dynamics of Local Exocytosis in Growth Cones by Netrin-1
A mouse model of human primitive neuroectodermal tumors resulting from microenvironmentally-driven malignant transformation of orthotopically transplanted radial glial cells.
Interkinetic Nuclear Migration Is Centrosome Independent and Ensures Apical Cell Division to Maintain Tissue Integrity
Signal inhibition by a dynamically-regulated pool of mono-phosphorylated MAPK
A High Throughput Micro-Chamber Array Device for Single Cell Clonal Cultivation and Tumor Heterogeneity Analysis
Natural Loss of Mps1 Kinase in Nematodes Uncovers a Role for Polo-like Kinase 1 in Spindle Checkpoint Initiation
A geminivirus betasatellite damages the structural and functional integrity of chloroplasts leading to symptom formation and inhibition of photosynthesis
Potent and selective small-molecule MCL-1 inhibitors demonstrate on-target cancer cell killing activity as single agents and in combination with ABT-263 (navitoclax)
RGS Proteins and Septins Cooperate to Promote Chemotropism by Regulating Polar Cap Mobility
A mechanical microcompressor for high resolution imaging of motile specimens
Motif‐Designed Peptide Nanofibers Decorated with Graphene Quantum Dots for Simultaneous Targeting and Imaging of Tumor Cells
In situ biosynthesis of fluorescent platinum nanoclusters: Towards self-bio-imaging guided cancer theranostics
Facile synthesis of fluorescent Au/Ce nanoclusters for high-sensitive bioimaging
Primary cilia enhance kisspeptin receptor signaling on gonadotropin-releasing hormone neurons
Remodeling of secretory compartments creates CUPS during nutrient starvation
Imaging Approach to Mechanistic Study of Nanoparticle Interactions with the BloodÀBrain Barrier
Anisotropic cell-to-cell spread of vaccinia virus on microgrooved substrate