sCMOS technology is rapidly gaining recognition as the ‘new interline’, particularly in the field of cell microscopy. Interline CCD technology has been the dominant detector for fluorescence microscopy for almost 15 years, the benchmark sensor being a 1.4 megapixel. 6.45 µm pixel size device, offering relatively low read noise (typically between 5 and 8 e- rms) at modest frame rates of 11-12 fps.
Fundamentally, sCMOS technology was conceptualized to offer a better alternative to interline CCDs. Indeed, Andor’s Zyla sCMOS offers dramatically higher performance, yet remains within the same price bracket as interline cameras, and is ideally placed to become the new gold standard 'workhorse' laboratory detector.
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