Global Innovators In Scientific Cameras, Microscopy & Spectroscopy Systems | Andor

Neo and Zyla sCMOS Cameras

Scientific CMOS (sCMOS) is a breakthrough technology that offers an advanced set of performance features that render it ideal to high fidelity, quantitative scientific measurement. The multi-megapixel sensors offers a large field of view and high resolution, without compromising read noise, dynamic range or frame rate.

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Find the perfect sCMOS camera for your research.



Unlike any CCD or CMOS camera to come before, Andor's multi-megapixel sCMOS cameras are unique in their ability to combine ultra-low noise, extremely rapid frame rates, wide dynamic range, large field of view and high-resolution. The Andor sCMOS portfolio ensures a viable technical and commercial solution to an extremely broad range of research and OEM application and design requirements.

Features and Benefits

Features Benefits
NEW QE up to > 80% (Zyla 4.2 PLUS) Highest available photon capture efficiency across visible/NIR, optimized for all common fluorophores.
NEW Market Leading USB 3.0 Speed Superb USB 3.0 data transfer efficiency and Zyla’s unique 12-bit high speed mode deliver up to 53 fps full resolution, 77% faster than competing sCMOS. Follow dynamic processes with improved temporal resolution.
Rolling and Global (Snapshot) shutter Maximum exposure and readout flexibility across all applications. Snapshot for 'interline CCD mode' freeze frame capture of fast moving/changing events. Sub-microsecond inter-frame gap, ideal for PIV
Down to sub-electron read noise Offers lower detection limit than any CCD.
100 fps (Camera Link) Zyla offers '10-tap' Camera Link for maximum sustained frame rates. Burst to 4GB on-head memory on Neo.
Multi-megapixel sensor formats and 6.5 μm pixels Delivers extremely sharp resolution over a large field of view, up to 22mm diagonal; ideal for cell microscopy, astronomy and high throughput 'area scanning' applications.
Dual-Gain Amplifiers Maximum well depth and lowest noise simultaneously, affording extended dynamic range of up to 33,000:1.
12-bit and 16-bit modes 12-bit for smaller file size and absolute fastest frame rates through USB 3.0; 16-bit for full dynamic range.
NEW Better than 99.8% linearity Unparalleled quantitative accuracy of measurement across the full dynamic range (> 99.9% for low light range)
TE cooled Neo offers vacuum cooling to -40 °C for lowest possible darkcurrent. Zyla offers 0 °C cooling in up to 35 °C ambient, with only 0.10 e-/pix/sec darkcurrent.
Hardware Timestamp FPGA generated timestamp with 25ns accuracy.
Dynamic Baseline Clamp Essential to ensure quantitative accuracy across the image area and between successive images of a kinetic series.
Spurious Noise Filter Real time FPGA filter that identifies and compensates for spurious high noise pixels.
GPU Express Simplify and optimize data transfers from camera to Graphical Processing Unit (GPU) card to facilitate accelerated GPU processing as part of the acquisition pipeline.
Comprehensive trigger modes and I/O Communication and synchronization within intricate experimental set-ups.

Specification Sheets


sCMOS Technology

What is sCMOS

Scientific CMOS, or sCMOS, is a breakthrough technology based on next-generation CMOS Image Sensor (CIS) design and fabrication techniques. sCMOS is finding recognition as a True scientific grade CIS, capable of out-performing most scientific imaging devices on the market today. This is a result of an advanced set of performance features that render it absolutely ideal to high fidelity, quantitative scientific measurement.

sCMOS technology stands alone in its ability to simultaneously deliver on many key performance parameters, overcoming the 'trade-offs' that are inherent to current scientific imaging technology standards, and eradicating the performance drawbacks that have traditionally been associated with conventional CMOS imagers.

Unlike previous generations of CMOS and CCD-based sensors, sCMOS is uniquely capable of simultaneously offering:

  • Extremely low noise
  • Rapid frame rates
  • Wide dynamic range
  • High resolution
  • Large field of view

sCMOS – No compromise

The multi-megapixel sensors offer a large field of view and high resolution, without compromising read noise, dynamic range or frame rate. Read noise is exceptional, even when compared to the highest performance ‘slow-scan’ CCDs. The fact that the sCMOS device can achieve down to sub 1 electron read noise while reading out up to 5.5 megapixels at 30 frames/sec renders it truly extraordinary in the market. Furthermore, the sensor is capable of achieving 100 full frames/sec with a read noise down to 1.1 electrons. By way of comparison, the lowest noise Interline CCD, reading out only 1.4 megapixels at ~ 16 frames/sec would do so with ~ 10 electrons read noise.

Comparison between Neo sCMOS and Interline CCD The low noise readout is complemented by up to 33,000:1 dynamic range. Usually, for CCDs or EMCCDs to reach their highest dynamic range values, there needs to be a significant compromise in readout speed, yet sCMOS can achieve this value while delivering high frame rates. The unique dual amplifier architecture of sCMOS allows for high dynamic range by offering a large well depth, despite the relatively small 6.5 μm pixel size, alongside lowest noise. A 1.4 megapixel Interline CCD with similarly small pixels achieves only ~1,800:1 dynamic range at 16 frames/sec.

Parameter Zyla sCMOS Interline CCD
Sensor Format 4.2 megapixel 1.4 to 4 megapixel
Pixel Size 6.5 μm 6.45 to 7.4 μm
Read Noise 0.9 median (1.4 rms) e- @ 30 fps
1.1 median (1.7 rms) e- @ 100 fps
4-10 e-
Full Frame Rate (max.) 100 fps CameraLink, 53 fps USB 3.0 3 to 16 fps
Quantum Efficiency (QE) 82% 60%
Dynamic Range 33,000:1 (@ 30 fps) ~ 3,000:1 (@ 11 fps)

Table 1 - Comparison summary of Zyla 4.2 USB 3.0 sCMOS camera with typical performance specifications of interline CCD.

Scientific CMOS (sCMOS) Architecture

The sensor features a split readout scheme in which the top and bottom halves of the sensor are read out independently. Each column within each half of the sensor is equipped with dual column level amplifiers and dual analog-to- digital converters (ADC), represented as a block diagram in below. This architecture was designed to minimize read noise and maximize dynamic range simultaneously.

The dual column level amplifier/ADC pairs have independent gain settings, and the final image is reconstructed by combining pixel readings from both the high gain and low gain readout channels to achieve a wide intra-scene dynamic range from such a small pixel pitch.

Each pinned-photodiode pixel has either 4 or 5 transistors (‘4T’ or ‘5T’ design). 5T architecture enables the novel ‘Global shutter’ mode (described in more detail below). The sensor is integrated with a microlens array that serves to focus much of the incident light per pixel away from the transistors and onto the exposed silicon, enhancing the QE (analogous to use of microlenses in interline CCDs to focus light away from the column masks).

The sensor is configured to offer low dark current and extremely low read noise with True correlated double sampling (CDS). The sensor also has anti-blooming of >10,000:1, meaning that the pixels can be significantly oversaturated without charge spilling into neighboring pixels. It is also possible to use the anti-blooming capability to hold all or parts of the sensor in a state of ‘reset’, even while light is falling on these pixels. In the 5T sensor design of the Neo 5.5 and Zyla 5.5, the time to transfer charge after the exposure is complete is less than 1μs, rendering the sensor useful for fast electronic shuttering and ‘double exposure’ techniques such as Particle Imaging Velocimetry (PIV).


Options and Accessories

Windows for cameras:

The standard window has been selected to satisfy most applications. However, other options are available. The alternative camera window code must be specified at time of ordering.

To view and select other window options please refer to the Camera Windows Supplementary Specification Sheet which gives the transmission characteristics, product codes and procedure for entering the order. Further detailed information on the windows can be found in the Technical note – ‘Camera Windows: Optimizing for Different Spectral Regions

The following accessories are available:

XW-RECR Re-circulator for enhanced cooling performance.
ACC-XW-CHIL-160 Oasis 160 Ultra compact chiller unit.
OA-CNAF C-mount to Nikon F-mount adapter.
OA-COFM C-mount to Olympus F-mount adapter.
OA-CTOT C-mount to T-mount adapter.
OA-ECAF Auto extension tubes (set of 3) for Canon AF.
ACC-MEC-05609 CS-mount adapter.
ACM-05574 F-mount adapter.
OA-ECMT Auto extension tubes (set of 3) for C-mount.
OA-ENAF Auto extension tubes (set of 3) for Nikon AF.
ACC-ASE-02992 5 meter Camera Link connector cable. Note, order x2 if using with Zyla Camera Link 10-tap models.
ACC-ASE-06962 10 meter active Camera Link connector cable, including power supply. For use with Zyla 10-tap Camera Link models.
ACC-NEOFOX-3TAP-30M 30 meter fibre-optic extender solution for use with Neo 5.5.
ACC-NEOFOX-3TAP-100M 100 meter fibre-optic extender solution for use with Neo 5.5.
ACC-ZYLFOX-10TAP-30M 30 meter fibre-optic extender solution for use with Zyla Camera Link 10-tap.
ACC-ZYLFOX-10TAP-100M 100 meter fibre-optic extender solution for use with Zyla Camera Link 10-tap.
WKST-1 WIN PC Workstation for up to 100 fps continuous spooling to hard drives, acquiring up to 120,000 12-bit full resolution images: Dell T7610, 2.3 GHz Six Core, 8 GB RAM, 4 x 250GB SSD hard drive configured in RAID 0.
WKST-2 WIN PC Workstation for up to 30 fps continuous spooling to RAM, acquiring up to 60,000 12-bit full resolution images: Dell T3610, 3.6 GHz Quad Core, 8 GB RAM, 2 x 250 GB SSD hard drives configured in RAID 0.
WKST-3 WIN PC Workstation for up to 100 fps continuous spooling to RAM, acquiring up to 6,000 12-bit full resolution images: Dell T3610, 3.6 GHz Quad Core, 64 GB RAM

For full details on the computer specifications required for Andor sCMOS cameras, please visit


The Andor Learning Center hosts a wide range of case studies, technical articles and webinars to guide you through the many features of our portfolio.


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